Table 3

Univariable and multivariable associations between clinical factors and VTE

VariableFactorNVTE no. (%)Univariable**Multivariable**
HR95% CIP valueHR95% CIP value
22829 (13)
Age at treatment, years≤65
>65
110
118
15 (14)
14 (12)
1.120.54 to 2.300.77
GenderFemale748 (11)
Male15421 (14)1.30.57 to 2.930.53
History of VTENo20826 (13)
Yes203 (15)1.190.36 to 3.880.77
Anticoagulation with/without prior DVT at treatment startNo21724 (11)
Yes115 (45)4.291.83 to 10.0<0.0014.141.60 to 10.70.003
History of ATENo21927 (12)
Yes92 (22)1.700.46 to 6.280.43
History of CADNo19922 (11)
Yes297 (24)2.270.98 to 5.240.062.711.16 to 6.290.02
Stage at treatment startIII432 (5)
IV18527 (15)3.260.77 to 13.860.11
ICISingle16115 (9)
Double6714 (21)2.411.17 to 4.980.022.701.28 to 5.700.009
Brain metastates at treatment startNo20323 (11)
Yes256 (24)2.250.92 to 5.490.08
Khorana Score at treatment start015415 (10)
≥16914 (20)2.281.10 to 4.710.032.241.06 to 4.740.03
  • *Univariable and multivariable Cox proportional hazard analysis calculated with death as competing risk. Bold type indicates p values <0.05.

  • ATE, arterial thromboembolism; CAD, coronary artery disease; DVT, deep venous thrombosis; VTE, venous thromboembolism.