Table 3

Univariable and multivariable associations between clinical factors and VTE

Variable	Factor	N	VTE no. (%)	Univariable**			Multivariable**
Variable	Factor	N	VTE no. (%)	HR	95% CI	P value	HR	95% CI	P value
		228	29 (13)
Age at treatment, years	≤65 >65	110 118	15 (14) 14 (12)	1.12	0.54 to 2.30	0.77
Gender	Female	74	8 (11)
Gender	Male	154	21 (14)	1.3	0.57 to 2.93	0.53
History of VTE	No	208	26 (13)
History of VTE	Yes	20	3 (15)	1.19	0.36 to 3.88	0.77
Anticoagulation with/without prior DVT at treatment start	No	217	24 (11)
Anticoagulation with/without prior DVT at treatment start	Yes	11	5 (45)	4.29	1.83 to 10.0	<0.001	4.14	1.60 to 10.7	0.003
History of ATE	No	219	27 (12)
History of ATE	Yes	9	2 (22)	1.70	0.46 to 6.28	0.43
History of CAD	No	199	22 (11)
History of CAD	Yes	29	7 (24)	2.27	0.98 to 5.24	0.06	2.71	1.16 to 6.29	0.02
Stage at treatment start	III	43	2 (5)
Stage at treatment start	IV	185	27 (15)	3.26	0.77 to 13.86	0.11
ICI	Single	161	15 (9)
ICI	Double	67	14 (21)	2.41	1.17 to 4.98	0.02	2.70	1.28 to 5.70	0.009
Brain metastates at treatment start	No	203	23 (11)
Brain metastates at treatment start	Yes	25	6 (24)	2.25	0.92 to 5.49	0.08
Khorana Score at treatment start	0	154	15 (10)
Khorana Score at treatment start	≥1	69	14 (20)	2.28	1.10 to 4.71	0.03	2.24	1.06 to 4.74	0.03

*Univariable and multivariable Cox proportional hazard analysis calculated with death as competing risk. Bold type indicates p values <0.05.
ATE, arterial thromboembolism; CAD, coronary artery disease; DVT, deep venous thrombosis; VTE, venous thromboembolism.