Univariate and multivariate analysis for evaluation of potential predictors associated with melanoma recurrence
| Potential predictor | Univariate association (HR, 95% CI, p value) | Multivariable association (HR, 95% CI, p value) | |
| Male gender (reference female) | 0.31 (0.11 to 0.94), p=0.038* | 0.48 (0.15 to 1.57), p=0.228 | |
| Age (per 10 years) | 0.71 (0.56 to 0.89), p=0.004* | 0.76 (0.59 to 0.98), p=0.037* | |
| Pre-PD-1 NLR | 1.10 (0.88 to 1.37), p=0.426 | – | |
| Pre-PD-1 LDH (per 50 U/L) | 0.98 (0.78 to 1.24), p=0.882 | – | |
| History of brain metastasis (reference no history) | 5.83 (1.78 to 19.04), p=0.004 * | 4.91 (1.50 to 16.11), p=0.009* | |
| Post-PD-1 NLR | 1.03 (0.70 to 1.53), p=0.872 | – | |
| Post-PD-1 LDH (per 50 U/L) | 2.19 (1.20 to 4.02), p=0.011* | 2.06 (1.06 to 4.00), p=0.032* | |
| Best objective response (reference CR) | PR 1.65 (0.34 to 7.99), p=0.531 | Overall p=0.403 | – |
| SD 2.96 (0.54 to 16.27), p=0.211 | |||
*p values <0.05.
CR, complete response; LDH, lactate dehydrogenase; NLR, neutrophil–lymphocyte ratio; PD-1, programmed cell death protein 1; PR, partial response; SD, stable disease.