Table 2

Management and outcomes

No (%)
CTCAE grade
 211 (42.3)
 313 (50.0)
 42 (7.7)
Refractory/resistant
 Steroid refractory12 (46.2)
 Steroid resistant14 (53.8)
Maximum steroid dose, prednisone equivalent
 Range (median)30–1250 mg (100 mg)
 ≥60 mg*21 (80.7)
Additional Immune modulator
 TNF antagonist21 (80.8)
 Mycophenolate mofetil9 (34.6)
 Cyclophosphamide1 (3.8)
 >15 (19.2)
Response to additional immune modulator
 Durable improvement10 (38.5)
 Transient improvement13 (50.0)
 No improvement3 (11.5)
Outcomes
 Mortality due to pneumonitis6 (23.1)
 Mortality due to infection3 (11.5)
  • *All patients with steroid refractory pneumonitis were treated with ≥60 mg.

  • CTCAE, common terminology criteria for adverse events; TNF, tumor necrosis factor.