Table 2

Univariate and multivariate analysis for objective response

Variables		Univariate	Multivariate
		P value	Full model 1*	Full model 2†	Reduced model
		P value	P value	P value	OR	95% CI	P value
Age (years)	<67	0.337
Age (years)	≥67
Sex	Male	0.660
Sex	Female
ECOG PS		0.533
	0	0.271
	1	0.405
	≥2	Ref.
IMDC risk		0.108	0.164	0.151
	Favorable	0.463	0.590	0.470
	Intermediate	0.045	0.407	0.582
	Poor	Ref.	Ref.	Ref.
Histology	Clear cell	0.076	0.136	0.119
Histology	Non-clear cell
Liver metastases	Presence	0.113
Liver metastases	Absence
Brain metastases	Presence	0.076	0.197	0.246
Brain metastases	Absence
Previous nephrectomy	Presence	0.046	0.307	0.267
Previous nephrectomy	Absence
No. of previous systemic therapies		0.363
	1	0.964
	2	0.294
	≥3	Ref.
Baseline LDH (IU/L)	<333	0.513
Baseline LDH (IU/L)	≥333
Baseline NLR	<3.0	0.454
Baseline NLR	≥3.0
Baseline CRP level (mg/L)	<10	0.337	0.567	–
Baseline CRP level (mg/L)	≥10
Baseline CRP level (mg/L)	Continuous	0.134	–	0.371
Early CRP kinetics		<0.001	0.002	0.004			<0.001
	CRP flare-responder	<0.001	<0.001	0.001	39.9	4.94–911	<0.001
	CRP responder	0.113	0.114	0.163	5.45	0.69–115	0.113
	Non-CRP responder	Ref.	Ref.	Ref.	Ref.

*Baseline CRP level was used for a categorical analysis.
†Baseline CRP level was evaluated as a continuous variable.
CRP, C-reactive protein; ECOG PS, Eastern Cooperative Oncology Group performance status; IMDC, International Metastatic Renal Cell Carcinoma Database Consortium; LDH, lactate dehydrogenase; NLR, neutrophil-to-lymphocyte ratio; No., number; ref., reference.