Blood biomarkers: lymphocytes (G/L), leucocytes (G/L), eosinophils (G/L), C reactive protein (CRP) (mg/dL), lactate dehydrogenase (LDH) and S100 (ug/L) correlated with response rates
| Baseline laboratory parameters and response rates | ||||
| CR N (%) | SD N (%) | PR N (%) | PD N (%) | |
| LDH (U/L) | ||||
| Norm | 27 (37.0) | 2 (2.7) | 12 (16.4) | 13 (17.8) |
| >ULN | 6 (8.2) | 2 (2.7) | 3 (4.1) | 8 (11.0) |
| Leucocytes (G/L) | ||||
| Norm | 33 (44.6) | 4 (5.4) | 12 (16.2) | 17 (23.0) |
| <LLN | 2 (2.7) | – | – | – |
| >ULN | 2 (2.7) | – | – | 4 (5,4) |
| Lymphocytes (G/L) | ||||
| Norm | 32 (43.2) | 4 (5.4) | 9 (12.2) | 18 (24.3) |
| <LLN | 3 (4.1) | – | 2 (2.7) | 3 (4.1) |
| >ULN | 1 (1.4) | – | 1 (1.4) | – |
| Eosinophils (G/L) | ||||
| Norm | 35 (47.9) | 2 (2.7) | 12 (16.4) | 17 (23.3) |
| <LLN | – | 1 (1.4) | – | 2 (2.7) |
| >ULN | 1 (1.4) | 1 (1.4) | – | 2 (2.7) |
| S100 (ug/L) | ||||
| Norm | 24 (38.1) | – | 5 (7.9) | 8 (12.7) |
| >ULN | 10 (15.9) | 2 (3.2) | 5 (7.9) | 9 (14.3) |
| CRP (mg/dL) | ||||
| Norm | 18 (27.7) | – | 3 (4.6) | 7 (10.8) |
| >ULN | 16 (24.6) | 3 (4.6) | 6 (9.2) | 37 (18.5) |
CR, complete response; LLN, lower limit of normal; PD, progressive disease; PR, partial response; SD, stable disease; ULN, upper limit of normal.