Response and PD patterns and their correlations with PPS (bivariate analysis, n=166)
| PPS (months)* | ||
| Bivariate analysis | HR (95% CI) | P value |
| Response pattern | ||
| Tumor percent change (%)† | 1.005 (1.002 to 1.009) | 0.005 |
| Time to nadir (months)† | 0.959 (0.904 to 1.018) | 0.17 |
| PFS (months)† | 0.959 (0.921 to 0.998) | 0.04 |
| PD pattern | ||
| General PD pattern‡ | 2.261 (1.469 to 3.480) | <0.001 |
| Number of involved organ† | 1.427 (1.187 to 1.715) | <0.001 |
| Target lesion measurement† | 1.010 (1.004 to 1.016) | <0.001 |
| Enlargement dynamics† | 1.017 (1.005 to 1.029) | 0.006 |
| LDH elevation at PD§ | 2.735 (1.695 to 4.413) | <0.001 |
| LDH elevation dynamics¶ | 1.007 (1.004 to 1.009) | <0.001 |
| Resistance type** | 0.503 (0.288 to 0.879) | 0.02 |
*Cox proportional hazards regression model, adjusted for baseline target lesion size.
†As continuous variables.
‡Dichotomous variable, defined as both new lesion(s) and enlargement vs either new lesion(s) or enlargement only, with the latter as the reference group.
§Dichotomous variable (normal vs elevated, normal as the reference).
¶Continuous variable, compared with last pre-PD LDH level, unit as percent change per month.
**Dichotomous variable, primary resistance as the reference group.
LDH, lactate dehydrogenase; PD, disease progression; PFS, progression-free survival; PPS, post-progression survival .