Table 3

Response and PD patterns and their correlations with PPS (bivariate analysis, n=166)

PPS (months)*
Bivariate analysisHR (95% CI)P value
Response pattern
 Tumor percent change (%)†1.005 (1.002 to 1.009)0.005
 Time to nadir (months)†0.959 (0.904 to 1.018)0.17
 PFS (months)†0.959 (0.921 to 0.998)0.04
PD pattern
 General PD pattern‡2.261 (1.469 to 3.480)<0.001
 Number of involved organ†1.427 (1.187 to 1.715)<0.001
 Target lesion measurement†1.010 (1.004 to 1.016)<0.001
 Enlargement dynamics†1.017 (1.005 to 1.029)0.006
 LDH elevation at PD§2.735 (1.695 to 4.413)<0.001
 LDH elevation dynamics¶1.007 (1.004 to 1.009)<0.001
Resistance type**0.503 (0.288 to 0.879)0.02
  • *Cox proportional hazards regression model, adjusted for baseline target lesion size.

  • †As continuous variables.

  • ‡Dichotomous variable, defined as both new lesion(s) and enlargement vs either new lesion(s) or enlargement only, with the latter as the reference group.

  • §Dichotomous variable (normal vs elevated, normal as the reference).

  • ¶Continuous variable, compared with last pre-PD LDH level, unit as percent change per month.

  • **Dichotomous variable, primary resistance as the reference group.

  • LDH, lactate dehydrogenase; PD, disease progression; PFS, progression-free survival; PPS, post-progression survival .