Table 1

Progression pattern overview (n=166)

Progression pattern
Categorical metricsNumber (%)
Resistance type
 Primary resistance123 (74)
 Secondary resistance43 (26)
Number of involved organ(s)
 180 (48)
 250 (30)
 >=336 (22)
General progression pattern
 Enlargement only41 (25)
 New lesion(s) only42 (25)
 Both83 (50)
LDH at PD
 Normal72 (43)
 Elevated79 (48)
 NA15 (9)
Continuous metricsMedian (range)
Target lesion size at PD (mm)*49.0 (0 to 415.0)
Tumor enlargement dynamics†
 Percent change from last evaluation (%)26.2 (−100.0 to 241.0)
 Percent change from last evaluation (%) per month10.0 (−28.6 to 109.1)
LDH elevation dynamics‡
 Percent change from last evaluation (%)6.2 (−33.7 to 354.6)
 Percent change from last evaluation (%) per month7.9 (−49.7 to 409.2)
  • *Thirteen patients with no available target lesion size data at PD.

  • †Eighteen patients with no available tumor enlargement dynamics data.

  • ‡Twenty-four patients without LDH dynamics data at PD.

  • LDH, lactate dehydrogenase; NA, not available; PD, disease progression.