Best overall response and overall response rate among molecular subtypes
| Pathogenic or likely pathogenic n=56 | VUS n=45 | |
| Best response, n (%) | ||
| Complete response (CR) | 2 (4%) | 1 (2%) |
| Partial response (PR) | 28 (50%) | 5 (11%) |
| Stable disease | 12 (21%) | 15 (33%) |
| Progressive disease | 13 (23%) | 19 (42%) |
| Not evaluable | 1 (1.8%) | 5 (11%) |
| Overall response (CR+PR), n (%) (95% CI) | 30 (54%) (40% to 67%) | 6 (13%) (5% to 27%) |
| OR of CR+PR (95% CI) | 7.5 (2.9 to 22.3), p=0.0009 | Reference (1.0) |
VUS, variants of unknown significance.