Table 2

Multivariate Cox regression model of OS and DSS for B cell activation signature

Covariates	OS		DSS
Covariates	HR (95% CI)	P value	HR (95% CI)	P value
B cell activation (low vs high/medium)	4.4 (1.8 to 11)	0.001	12 (3.4 to 39)	<0.001
HPV genotype (non-HPV16+ vs HPV16+)	1.9 (0.8 to 4.6)	0.14	1.1 (0.34 to 3.6)	0.86
Anatomical site (non-OPSCC vs OPSCC)	2.6 (0.73 to 9)	0.14	0.9 (0.2 to 4)	0.89
T stage (III/IV vs I/II)	1.8 (0.64 to 5.2)	0.26	2.5 (0.69 to 8.7)	0.16
N stage (N0+ vs N0)	1.3 (0.52 to 3.2)	0.58	0.85 (0.27 to 2.7)	0.78

DSS, disease-specific survival; HPV, human papillomavirus; N stage, node stage; OPSCC, oropharyngeal squamous cell carcinoma; OS, overall survival; T stage, tumor stage.