Table 2

Univariable and multivariable HRs for prognostic factors

	Training	n=529			Validation	n=542
Prognostic factor	Univariable HR (95% CI)	P value	Multivariable HR (95% CI)	P value	Univariable HR (95% CI)	P value	Multivariable HR (95% CI)	P value
NLR <6/≥6	*1.68 (1.25 to 2.27)*	*0.001*	0.97 (0.60 to 1.55)	0.882	*2.07 (1.50 to 2.86)*	*<0.0001*	0.75 (0.45 to 1.26)	0.275
PLR <270/≥270	1.10 (0.81 to 1.45)	0.550	0.76 (0.49 to 1.19)	0.234	*1.55 (1.12 to 2.13)*	0.008	0.94 (0.52 to 1.70)	0.842
OIS >40/≤40	*2.78 (1.78 to 4.34)*	*<0.0001*	*1.97 (1.19 to 3.26)*	*0.008*	*2.83 (1.80 to 4.45)*	*<0.0001*	*2.48 (1.47 to 4.20)*	*0.001*
mGPS 0/2	*5.12 (2.57 to 10.22)*	*<0.0001*	2.35 (0.77 to 7.14)	0.132	*2.18 (1.32 to 3.60)*	*0.002*	1.37 (0.18 to 10.78)	0.764
PI 0/2	*5.61 (2.36 to 13.34)*	*<0.0001*	1.41 (0.13 to 15.76)	0.781	*2.71 (1.49 to 4.90)*	*0.001*	1.76 (0.74 to 4.17)	0.200
Sex (Female/male)	*1.38 (1.03 to 1.862)*	*0.032*	0.69 (0.45 to 1.07)	0.097	*1.40 (1.02 to 1.92)*	*0.039*	0.86 (0.51 to 1.45)	0.576
Age <65/≥65	*2.22 (1.60 to 3.06)*	*<0.0001*	1.47 (0.93 to 2.33)	0.103	*2.56 (1.78 to 3.67)*	*<0.0001*	*2.80 (1.50 to 5.22)*	*0.001*
Comorbid burden 0/≥2	*1.86 (1.24 to 2.80)*	*0.003*	1.28 (0.71 to 2.30)	0.412	*2.40 (1.53 to 3.76)*	*<0.0001*	2.19 (0.89 to 5.39)	0.090
Malignancy status Remission/active	*1.55 (1.09 to 2.21)*	*0.015*	1.60 (0.95 to 2.72)	0.080	1.20 (0.86 to 1.65)	0.284	1.16 (0.69 to 1.95)	0.575
Anticancer therapy at COVID-19 diagnosis No/yes	*0.59 (0.44 to 0.79)*	*<0.001*	0.65 (0.41 to 1.02)	0.063	*0.72 (0.53 to 0.97)*	*0.032*	0.94 (0.54 to 1.63)	0.813

Prognostic factors for both the training (n=529) and validation (n=542) are shown with their corresponding univariable and multivariable HRs with 95% CIs and p values. Univariable HRs were calculated through logistic Cox regression, and multivariable HRs were calculated through Cox regression with conditional backward elimination. Statistical signifiance indicated via bold and italics. HR, hazard ratio; NLR, neutrophil:lymphocyte ratio; PLR, platelet:lymphocyte ratio; OIS, OnCovid Inflammatory Score; mGPS, modified Glasgow Prognostic Score; PI, Prognostic Index.
Bold and italicized values are statistically significant (P<0.05).
mGPS, modified Glasgow prognostic score; NLR, neutrophil:lymphocyte ratio; OIS, OnCovid inflammatory score; PI, prognostic index; PLR, platelet:lymphocyte ratio.