Association between pCR and changes in cellular marker levels between baseline and week 3
| Marker | Stroma | Tumor | ||||
| pCR, n | Non- pCR, n | OR* (95% CI) | pCR, n | Non- pCR, n | OR* (95% CI) | |
| CD4 | ||||||
| Increase | 17 | 30 | 1.00 | 17 | 28 | 1.00 |
| Decrease | 7 | 12 | 1.24 (0.39 to 3.96) | 7 | 14 | 1.27 (0.37 to 4.41) |
| P-trend | 0.260 | 0.249 | ||||
| CD8 | ||||||
| Increase | 22 | 28 | 1.00 | 21 | 28 | 1.00 |
| Decrease | 2 | 14 | 0.10 (0.01 to 0.66) | 3 | 14 | 0.28 (0.07 to 1.16) |
| P-trend | 0.522 | 0.198 | ||||
| CD4/CD8 | ||||||
| Increase | 15 | 18 | 1.00 | 12 | 20 | 1.00 |
| Decrease | 9 | 24 | 0.69 (0.21 to 2.30) | 12 | 22 | 0.79 (0.26 to 2.34) |
| P-trend | 0.711 | 0.205 | ||||
| T cell | ||||||
| Increase | 20 | 31 | 1.00 | 21 | 28 | 1.00 |
| Decrease | 4 | 11 | 0.60 (0.16 to 2.19) | 3 | 14 | 0.31 (0.07 to 1.41) |
| P-trend | 0.331 | 0.184 | ||||
| CD73 | ||||||
| Increase | 13 | 28 | 1.00 | 11 | 21 | 1.00 |
| Decrease | 11 | 14 | 1.64 (0.58 to 4.62) | 13 | 21 | 1.32 (0.44 to 3.94) |
| P-trend | 0.458 | 0.930 | ||||
| PD1 in CD4 | ||||||
| Increase | 13 | 13 | 1.00 | 18 | 19 | 1.00 |
| Decrease | 11 | 29 | 0.36 (0.12 to 1.07) | 6 | 23 | 0.25 (0.08 to 0.80) |
| P-trend | 0.213 | 0.023 | ||||
| PD1 in CD8 | ||||||
| Increase | 16 | 21 | 1.00 | 19 | 25 | 1.00 |
| Decrease | 8 | 21 | 0.53 (0.17 to 1.61) | 5 | 17 | 0.45 (0.12 to 1.63) |
| P-trend | 0.098 | 0.196 | ||||
| PDL1 | ||||||
| Increase | 15 | 22 | 1.00 | 18 | 27 | 1.00 |
| Decrease | 9 | 20 | 0.50 (0.16 to 1.59) | 6 | 15 | 0.53 (0.16 to 1.81) |
| p-trend | 0.781 | 0.652 | ||||
*OR adjusted for baseline marker value.
pCR, pathological complete response.