Change in marker levels between baseline and week 3
| Marker | Baseline, median (IQR) | Week 3, median (IQR) | Change, median (IQR) | P value for change |
| Stroma (cells/megapixel) | ||||
| CD4 | 63.9 (29.4–119.9) | 102.2 (50.8–199.2) | 29.1 (−8.0 to 112.1) | <0.001 |
| CD8 | 27.8 (17.6–42.0) | 52.1 (32.7–80.3) | 20.1 (0.0–42.1) | <0.001 |
| CD4/CD8 | 2.1 (1.1–3.8) | 2.3 (1.1–3.1) | 0.0 (−1.3 to 0.8) | 0.423 |
| T cell | 102.3 (50.0–167.8) | 168.4 (86.2–270.9) | 49.8 (5.3–153.9) | <0.001 |
| CD73 | 39.9 (25.8–73.3) | 51.2 (30.7–100.1) | 6.4 (−9.7 to 35.3) | 0.015 |
| PD1 in CD4 | 5.8 (3.1–15.0) | 6.1 (2.5–12.2) | −1.0 (−4.5 to 3.3) | 0.265 |
| PD1 in CD8 | 25.5 (11.5–43.4) | 31.9 (20.5–50.9) | 3.5 (−7.4 to 19.2) | 0.019 |
| PDL1 | 54.0 (15.8–146.4) | 68.1 (37.5–149.9) | 6.9 (−25.5 to 78.0) | 0.279 |
| Tumor (cells/megapixel) | ||||
| CD4 | 13.4 (3.9–29.3) | 24.9 (11.8–72.8) | 10.3 (−4.3 to 48.9) | 0.003 |
| CD8 | 19.0 (6.5–29.4) | 35.2 (17.1–74.9) | 21.6 (−1.4 to 43.8) | <0.001 |
| CD4/CD8 | 0.8 (0.3–2.2) | 0.8 (0.3–2.0) | 0.0 (−0.8 to 0.4) | 0.492 |
| T cell | 34.7 (13.6–88.5) | 85.8 (27.9–143.5) | 39.0 (−0.8 to 103.5) | <0.001 |
| CD73 | 33.1 (18.4–80.0) | 43.8 (18.4–74.5) | −1.3 (−25.7 to 22.9) | 0.982 |
| PD1 in CD4 | 11.0 (4.9–22.5) | 12.7 (4.2–33.3) | 1.8 (−5.6 to 10.9) | 0.144 |
| PD1 in CD8 | 15.6 (5.2–38.0) | 29.7 (14.3–44.7) | 9.5 (−5.1 to 26.5) | 0.001 |
| PDL1 | 35.0 (14.1–117.1) | 72.0 (22.5–194.8) | 32.3 (−6.6 to 112.7) | 0.003 |