Multivariate survival analysis
| HR | 95% CI for HR | P value | |
| Disease control rate* | |||
| CAIX/I | NA | NA | 0.028 |
| CD8 | NA | NA | 0.005 |
| PFS | |||
| CAIX/I† (high) | 1.71 | 1.03 to 2.84 | 0.04 |
| CD8‡ (high) | 0.08 | 0.006 to 1.131 | 0.02 |
| OS | |||
| CAIX/I (high) | 1.68 | 0.87 to 3.22 | 0.11 |
| CD8 (high) | 0.065 | 0.001 to 3.78 | 0.081 |
| Programmed death-ligand 1 (PD-L1) | 0.98 | 0.93 to 1.02 | 0.20 |
*Disease control rate=CR, PR, or SD.
†CAIX/I=per cent area of CAIX/intensity of CAIX dichotomized.
‡CD8=CD8 T cells normalized to tumor area. Only variables significant in univariate analysis were included in multivariate model.
OS, overall survival; PFS, progression free survival.