Table 1

Simulation parameters in the ODE model

SymbolParameter (dimension)Default value (range*)
ρ Tumor growth rate (cells/day)1 (0–7)
ξ Relative killing rate (cells/day)0.001 (0–0.05)
h Michaelis constant (cells)571
δ Death rate of immune cells (cells/day)0.01958
αConversion rate of naive T cells into specific T cells (cells/day)0.0025
pS Total production rate of effector T cells from lymph nodes (cells/day)1
mS Migration rate from lymph node to tumor microenvironment (cells/day)1
  • *If not fixed.

  • ODE, ordinary differential equation.