PK parameters of TNB-585 in cynomolgus monkeys
| Parameter | Units | 0.07 mg/kg | 0.97 mg/kg | 10.39 mg/kg | |||
| Mean | SD | Mean | SD | Mean | SD | ||
| Cmax | µg/mL | 2.0 | 0.1 | 24.5 | 1.1 | 344 | 39 |
| Cmax/D | (µg/mL)/(mg/kg) | 28.7 | 1.7 | 25.3 | 1.1 | 33.1 | 3.8 |
| t1/2 | Days | 9.9 | 0.7 | 9.8 | 3.0 | 11 | 1.3 |
| AUCinf | µg/mL*days | 10.4 | 0.8 | 178 | 48.9 | 2500 | 118 |
| AUCinf/D | (µg/mL*days)/(mg/kg) | 148 | 10.8 | 184 | 50.4 | 241 | 11.3 |
| % Extrap | % | 21.9 | 1.8 | 22.6 | 9.8 | 27.1 | 2.7 |
| CL | mL/day/kg | 6.8 | 0.5 | 5.7 | 1.6 | 4.2 | 0.2 |
| Vss | mL/kg | 86.8 | 1.3 | 72.2 | 2.6 | 62.7 | 2.5 |
AUCinf: area under the serum concentration-time curve from time zero to infinity; AUCinf/D, dose-adjusted area under the serum concentration-time curve; Cmax: maximum serum drug concentration ; CL, serum clearance; Cmax/D, dose-adjusted maximum serum drug concentration; % Extrap, area under the serum concentration-time curve extrapolated from time t to infinity as a percentage of total AUC; t1/2, half-life; Vss, apparent volume of distribution at steady state.