Table 3

Multivariate Cox proportional hazard models of TLS+ patients

VariableHR (95% CI)P value
Model A*
Low fraction of B-cells AID+2.74 (1.11 to 6.76)0.028
Curative-intent resection0.17 (0.05 to 0.54)0.003
Model B
Low fraction B-cells expressing CD21+0.29 (0.10 to 0.82)0.02
Female sex0.32 (0.12 to 0.88)0.03
Curative-intent resection0.24 (0.08 to 0.70)0.01
  • Includes only patients with at least one TLS (n=30). Model assumptions verified with Schoenfeld residuals with a significance level of <0.01.

  • *Model stratified by patient sex to control for Schoenfeld residual <0.01.

  • TLS, tertiary lymphoid structure.