Table 2

Univariate and multivariate analyses for overall survival

VariablesUnivariate analysisMultivariate analysis
HR (95% CI)P valueHR (95% CI)P value
Baseline fibrinogen
(≥5 ng/mL vs <5 ng/mL)
2.3 (1.4 to 3.8)0.0012*1.9 (0.9 to 3.6)0.06
On-treatment fibrinogen
(≥4 ng/mL vs <4 ng/mL)
3.8 (2.1 to 6.9)<0.0001*3.3 (1.4 to 8.2)0.008*
Baseline NLR
(≥8 vs <8)
2.3 (1.4 to 3.9)0.0011*1.2 (0.5 to 1.6)0.6
On-treatment NLR
(≥4 vs <4)
5.2 (2.4 to 11.5)<0.0001*3.7 (1.6 to 8.7)0.003*
P16 status
(negative vs positive)
0.53 (0.3 to 0.8)0.017*1.1 (0.4 to 3.2)0.78
  • *P value < 0.05

  • NLR, neutrophil-to-lymphocyte ratio.