Power of serial CT and PET/MRI parameters to predict progressive disease
| Cut-off (%) | Sensitivity % (N) | Specificity % (N) | PPV% (N) | NPV% (N) | Accuracy % (N) | |
| Changes between baseline and week 2 | ||||||
| Δdiameter0-2 | 20 | 11.1 (1/9) | 100 (16/16) | 100 (1/1) | 66.7 (16/24) | 68.0 (17/25) |
| ΔSUVmax0-2 | 30 | 33.3 (3/9) | 93.8 (15/16) | 75.0 (3/4) | 71.4 (15/21) | 72.0 (18/25) |
| ΔPTV0-2 | 30 | 66.7 (6/9) | 62.5 (10/16) | 50.0 (6/12) | 76.9 (10/13) | 64.0 (16/25) |
| ΔTLP0-2 | 30 | 66.7 (6/9) | 56.3 (9/16) | 46.2 (6/13) | 75 (9/12) | 60.0 (15/25) |
| ΔSUVmax0-2 | 10 | 66.7 (6/9) | 75.0 (12/16) | 60.0 (6/10) | 80 (12/15) | 72.0 (18/25) |
| ΔPTV0-2 | 45 | 66.7 (6/9) | 81.3 (13/16) | 66.7 (6/9) | 81.3 (13/16) | 76.0 (19/25) |
| ΔTLP0-2 | 60 | 66.7 (6/9) | 81.3 (13/16) | 66.7 (6/9) | 81.3 (13/16) | 76.0 (19/25) |
| Changes between baseline and week 6 | ||||||
| Δdiameter0-6 | 20 | 50.0 (3/6) | 100 (16/16) | 100 (3/3) | 84.2 (16/19) | 86.4 (19/22) |
| ΔSUVmax0-6 | 30 | 33.3 (2/6) | 100 (16/16) | 100 (2/2) | 80.0 (16/20) | 81.8 (18/22) |
| ΔPTV0-6 | 30 | 83.3 (5/6) | 87.5 (14/16) | 71.4 (5/7) | 93.3 (14/15) | 86.4 (19/22) |
| ΔTLP0-6 | 30 | 83.3 (5/6) | 87.5 (14/16) | 71.4 (5/7) | 83.3 (14/15) | 86.4 (19/22) |
| ΔSUVmax0-6 | 20 | 66.7 (4/6) | 100 (16/16) | 100 (4/4) | 88.9 (16/18) | 90.9 (20/22) |
| ΔPTV0-6 | 50 | 83.3 (5/6) | 93.8 (15/16) | 83.3 (5/6) | 93.8 (15/16) | 90.9 (20/22) |
| ΔTLP0-6 | 50 | 83.3 (5/6) | 93.8 (15/16) | 83.3 (5/6) | 93.8 (15/16) | 90.9 (20/22) |
NPV, negative predictive value; PET, positron emission tomography; PPV, positive predictive value; PTV, proliferative tumor volume; SUV, standardized uptake value; TLP, total lesion proliferation.