Table 2

Univariate analysis of prognostic factors correlated with OS and CSS

Variables	OS				CSS
	Training cohort		Validation cohort		Training cohort		Validation cohort
	HR (95% CI)	P value	HR (95% CI)	P value	HR (95% CI)	P value	HR (95% CI)	P value
Age (years)	1.94	0.059	1.62	0.341	1.89	0.129	1.21	0.713
≥66/<66	0.98–3.88	0.059	0.63–4.14	0.341	0.83–4.32	0.129	0.43–3.41	0.713
Gleason score 7 (4+3)−10/6–7 (3+4)	2.58	0.009	7.28	0.001	2.46	0.036	7.06	0.01
Gleason score 7 (4+3)−10/6–7 (3+4)	1.27–5.24	0.009	2.14–24.67	0.001	1.06–5.71	0.036	1.59–31.39	0.01
Tumor stage	2.14	0.025	5.5	<0.001	2.3	0.042	6.03	0.001
T3–4/T2	1.10–4.17	0.025	2.30–13.16	<0.001	1.03–5.13	0.042	2.06–17.71	0.001
Nodal metastasis	3.86	<0.001	5.72	0.021	4.45	<0.001	7.18	0.011
Present/Absent	1.90–7.83	<0.001	1.30–25.27	0.021	1.94–10.16	<0.001	1.59–32.56	0.011
Distal metastasis	5.83	<0.001	4.43	0.003	6.49	<0.001	7.27	<0.001
Present/Absent	2.63–12.93	<0.001	1.63–12.03	0.003	2.56–16.43	<0.001	2.48–21.30	<0.001
B7-H3	2.7	0.006	2.85	0.016	3.01	0.014	2.9	0.043
High/Low	1.33–5.50	0.006	1.21–6.68	0.016	1.26–7.24	0.014	1.03–8.17	0.043
HHLA2	2.73	0.007	3.7	0.003	3.44	0.008	3.06	0.034
High/Low	1.31–5.69	0.007	1.55–8.83	0.003	1.37–8.65	0.008	1.09–8.62	0.034

P values <0.05 marked in bold font are statistically significant.
CSS, cancer-specific survival; OS, overall survival.