Table 4

Multivariate analyses of prognostic factors correlated with OS and CSS with regard to B7 score

Variables	OS				CSS
	Training cohort		Validation cohort		Training cohort		Validation cohort
	HR (95% CI)	P value	HR (95% CI)	P value	HR (95% CI)	P value	HR (95% CI)	P value
Gleason score 7 (4+3)−10/6–7 (3+4)	1.46	0.37	3.64	0.043	1.24	0.682	3.15	0.147
Gleason score 7 (4+3)−10/6–7 (3+4)	0.64 to 3.37	0.37	1.04 to 12.73	0.043	0.45 to 3.41	0.682	0.67 to 14.87	0.147
Tumor stage	1.04	0.927	3.11	0.021	1.1	0.845	2.93	0.086
T3–4/T2	0.47 to 2.28	0.927	1.19 to 8.12	0.021	0.42 to 2.87	0.845	0.86 to 10.03	0.086
Nodal metastasis	2.66	0.023	2.55	0.243	3.3	0.019	2.69	0.233
Present/Absent	1.15 to 6.19	0.023	0.53 to 12.30	0.243	1.21 to 8.98	0.019	0.53 to 13.73	0.233
Distal metastasis	5.43	<0.001	1.57	0.434	6.53	<0.001	2.57	0.146
Present/Absent	2.36 to 12.52	<0.001	0.51 to 4.85	0.434	2.44 to 17.48	<0.001	0.72 to 9.14	0.146
B7 score	4.33	0.018	10.76	0.022	4.54	0.046	6.52	0.077
High/Low	1.29 to 14.56	0.018	1.41 to 82.50	0.022	1.03 to 20.02	0.046	0.82 to 52.09	0.077

P values <0.05 marked in bold font are statistically significant.
CSS, cancer-specific survival; OS, overall survival.