Table 3

Multivariate analysis of prognostic factors correlated with OS and CSS with regard to B7-H3 and HHLA2

Variables	OS				CSS
	Training cohort		Validation cohort		Training cohort		Validation cohort
	HR (95% CI)	P value	HR (95% CI)	P value	HR (95% CI)	P value	HR (95% CI)	P value
	HR (95% CI)	P value	HR (95% CI)	P value	HR (95% CI)	P value	HR (95% CI)	P value	Gleason score 7 (4+3)−10/6–7 (3+4)	1.51	0.344	4.52	0.018	1.21	0.723	3.95	0.08
0.65 to 3.52	1.30 to 15.71	0.42 to 3.46	0.85 to 18.34						Gleason score 7 (4+3)−10/6–7 (3+4)		0.344		0.018		0.723		0.08
Tumor stage	0.96	0.928	3.22	<0.001	1	0.999	3.08	0.07
T3–4/T2	0.43 to 2.17	0.928	1.24 to 8.40	<0.001	0.37 to 2.70	0.999	0.91 to 10.36	0.07
Nodal metastasis	2.3	0.065	1.6	0.609	2.69	0.061	1.54	0.667
Present/Absent	0.95 to 5.55	0.065	0.27 to 9.64	0.609	0.96 to 7.60	0.061	0.22 to 10.98	0.667
Distal metastasis	6.47	<0.001	2.35	0.212	7.65	<0.001	3.87	0.082
Present/Absent	2.76 to 15.18	<0.001	0.61 to 9.02	0.212	2.79 to 21.00	<0.001	0.84 to 17.76	0.082
B7-H3	2.03	0.082	1.39	0.47	2.13	0.13	1.27	0.674
High/Low	0.92 to 4.50	0.082	0.57 to 3.43	0.47	0.80 to 5.64	0.13	0.42 to 3.89	0.674
HHLA2	1.55	0.297	3.15	0.032	2.01	0.185	3.01	0.102
High/Low	0.68 to 3.53	0.297	1.10 to 9.00	0.032	0.72 to 5.66	0.185	0.80 to 11.30	0.102

P values <0.05 marked in bold font are statistically significant.
CSS, cancer-specific survival; OS, overall survival.