Table 1

The correlation of B7-H3 and HHLA2 expression with clinicopathological features in both cohorts

Variables	Training cohort							Validation cohort
	Patients no.	B7-H3 expression			HHLA2 expression			Patients no.	B7-H3 expression			HHLA2 expression
	Patients no.	Low	High	P value	Low	High	P value	Patients no.	Low	High	P value	Low	High	P value
Age (years)				0.15			0.15				0.034			0.647
<66	59	25	34		34	25		41	31	10		25	16
≥66	67	37	30		30	37		72	40	32		47	25
Gleason score				0.032			0.001				0.006			0.028
6–7 (3+4)	65	38	27		42	23		54	41	13		40	14
7 (4+3)–10	61	24	37		22	39		59	30	19		32	27
Tumor stage				0.006			0.049				0.001			0.031
T2	76	45	31		44	32		80	58	22		56	24
T3–4	50	17	33		20	30		33	13	20		16	17
Nodal metastasis				0.001			0.002				1			0.046
Absent	108	60	57		61	47		110	69	41		72	38
Present	18	2	7		3	15		3	2	1		0	3
Distal metastasis				0.324			0.052				0.145			0.709
Absent	116	59	52		62	54		105	68	37		66	39
Present	10	3	39		2	8		8	3	5		6	2
B7-H3 expression				–			0.002				–			0.02
Low	62	–	–		40	22		71	–	–		51	20
High	64	–	–		24	40		42	–	–		21	21

P values <0.05 marked in bold font are statistically significant.