Clinical characteristics of patients and statistical significance related to pneumonitis development
| Characteristic | Pneumonitis (n=12) | Non-pneumonitis (n=34) | P value |
| Age (years)—median (range) | 61.0 (47.0–76.0) | 63.5 (41.0–76.0) | 0.910 |
| Sex—n (%) | 1.000 | ||
| Male | 9 (75.0) | 25 (73.5) | |
| Female | 3 (25.0) | 9 (26.5) | |
| Histology—n (%)* | 0.316 | ||
| Adenocarcinoma | 9 (75.0) | 17 (50.0) | |
| Squamous | 3 (25.0) | 13 (38.2) | |
| No otherwise specified | 0 (0.0) | 4 (11.8) | |
| Smoking status—n (%) | 0.749 | ||
| Former | 6 (50.0) | 19 (55.9) | |
| Current | 6 (50.0) | 15 (44.1) | |
| Packs-year—median (range) | 57.0 (20.0–100.0) | 45.0 (22.0–114.0) | 0.196 |
| Clinical response—n (%) | 0.836 | ||
| Complete | 0 (0.0) | 2 (5.9) | |
| Partial | 10 (83.3) | 23 (67.6) | |
| Stable | 2 (16.7) | 9 (26.5) | |
| Pathological response—n (%)† | 0.480‡, 0.398§ | ||
| Complete | 9 (75.0) | 17 (58.6) | |
| Major | 0 (0.0) | 8 (27.6) | |
| Incomplete | 3 (25.0) | 4 (13.8) | |
| PFS (months)—median (95% CI) | NR | NR | 0.761 |
| OS (months)—median (95% CI) | NR | NR | 0.726 |
| No cycles—N (%) | 0.409 | ||
| ≤3 cycles | 1 (8.3) | 8 (23.5) | |
| >3 cycles | 11 (91.7) | 26 (76.5) |
*Four patients had no specified histology
†Five patients did not undergo surgery
‡Complete responses versus other
§Incomplete responses versus other
NR, not reported; OS, overall survival; PFS, progression-free survival.