Scoring matrix
| Condition | Assigned point value |
| Is this mutation not present in the highest frequency cluster as determined by PyClone? | 1 |
| Is the AF/MSAF ratio for this mutation <10%? | 1 |
| Is this mutation only detected in ctDNA or tissue DNA? | 1 |
AF, allele frequency; ctDNA, circulating tumor DNA; MSAF, maximum somatic allele frequency.