Table 3

Barcelona-Clínic Liver Cancer (BCLC) classification with stage definitions and typical survival outcomes

Stage definition (BCLC 2018 update)Estimated survival
Stage 0—Very early-stage Single nodule ≤2 cm;
ECOG PS 0*;
Preserved liver function
>5 years
Stage A—Early-stage Single or up to three nodules ≤3 cm;
ECOG PS 0*;
Preserved liver function
>5 years
Stage B—Intermediate-stage Multinodular;
ECOG PS 0*;
Preserved liver function
>2 to 5 years
Stage C—Advanced-stage Portal invasion;
Extrahepatic spread;
ECOG PS 1–2;
Preserved liver function
>1 year
Stage D—Terminal-stage ECOG PS 3–4;
End-stage liver function
3 months
  • *The American Association for the Study of Liver Disease (AASLD) recommends including ECOG PS 0 to 1 in stage 0, A and B, because of the significant overlap between PS 0 and PS 1

  • BCLC, Barcelona-Clinic Liver Cancer; ECOG, Eastern Cooperative Oncology Group; PS, performance status.