The standardized incidence ratio of TB in patients with cancer exposed to ICIs
| Standardized TB incidence rate* | 95% CI | TB incidence rate in general population* | 95% CI | Standardized incidence ratio | 95% CI | P value | |
| ICI exposure | |||||||
| Total | 494.4 | 492.3 to 496.5 | 61.4 | 60.6 to 62.1 | 8.1 | 8.0 to 8.2 | <0.001 |
| Male | 428.2 | 425.3 to 431.0 | 71.6 | 70.4 to 72.2 | 6.0 | 5.9 to 6.1 | <0.001 |
| Female | 559.3 | 556.1 to 562.5 | 51.4 | 50.4 to 52.3 | 10.9 | 10.7 to 11.1 | <0.001 |
| ICI non-exposure | |||||||
| Total | 502.6 | 500.5 to 504.8 | 61.4 | 60.6 to 62.1 | 8.2 | 8.1 to 8.3 | <0.001 |
| Male | 600.0 | 596.7 to 603.4 | 71.6 | 70.4 to 72.2 | 8.4 | 8.2 to 8.5 | <0.001 |
| Female | 407.1 | 404.4 to 409.9 | 51.4 | 50.4 to 52.3 | 7.9 | 7.8 to 8.1 | <0.001 |
*Indicates incidence rate per 100,000 person-years.
ICI, immune checkpoint inhibitor; TB, tuberculosis.