Companion dogs with naturally occurring mastocytoma treated with CFA
| Dog | MCT grade (Kiupel/Patnaik) | Dose CFA | Clinical notes, response to therapy, side effects | Disease-free interval | Survival expected vs actual (weeks) PI | Response |
| Rottweiler 7 y MN | High/3 | 0.05 | Permanent remission in injected unresectable tumor 5 weeks PI. Multiple de novo tumors from 4 months PI treated with surgery. Euthanased due to unrelated osteosarcoma. Side effects: local swelling, lethargy at 3 weeks post injection preceding mass regression. | 4 months | 8*/51 | Remission. Extended survival |
| Maltese X Shih Tzu 8 y FN | Low/1 | 0.05 | Gradual reduction in size PI. Tumor surgically resected 9 months post-treatment. Side effects: Nil reported | – | +104†/alive | Size reduction. |
| Maltese 13 y FN | High/3 | 0.05 | Advanced disease on presentation. Rapidly progressive disease PI. Side effects: swelling and limping. | – | 2*/2 | – |
| German shorthaired pointer 6 y MN | Low/2 | 0.05 | Permanent remission of injected tumor and distant untreated MCT 3 weeks PI. Euthanased after hemoptysis cause unknown. Side effects: nil reported within 12 months. Pruritus and coughing prior to euthanasia. | 16.75 months | 8–12*/67 | Remission. Extended survival |
| Staffordshire bull terrier 9 y MN | Low/2 | 0.1 | Static disease of injected tumor for 3 months. Euthanased for welfare reasons 6 months PI. Side effects: nil reported | – | ND/29 | Static disease 3 months. |
| Golden retriever 9 y FN | High/2 | 0.1 | Advanced disease on presentation. Rapidly progressive disease PI. Side effects: nil reported . | – | 2*/2 | – |
| Shar pei 6 y FN | High/3 | 0.1 | Advanced disease on presentation. Rapidly progressive disease PI. Side effects: local ulceration at injection site. | – | 12*/13 | – |
| Belgian Shepherd 12 y FN | Ungraded | 0.1 | Gradual progressive disease. Side effects: nil reported | – | +104†/alive | – |
| Staffordshire bull terrier 7 y FN | Low/1 | 0.2 | Gradual progressive disease. Side effects: nil reported | – | +104†/alive | – |
| Staffordshire bull terrier 12 y FN | Low/1 | 0.2 | Static disease. Side effects: central scab, pruritus. | – | +104†/alive | Static disease. |
| Jack Russell 7 y FN | Low/1 | 0.2 | Gradual progressive disease. Surgical removal 16 months post Tx. Local reoccurrence 6.5 months post-surgery. Side effects: pruritus | – | +104†/alive | – |
| Staffordshire bull terrier 6 y FN | Low/2 | 0.2 | Rapid progressive disease PI. Surgical removal of masses 19/8/14 Side effects: nil reported | – | ND/alive | – |
| Staffordshire bull terrier 8 y FN | Ungraded | 0.2 | Gradual reduction in size PI. Side effects: nil reported | – | ND/alive | Size reduction |
| Miniature poodle 9 y FN | Low/2 | 0.1 | Permanent remission of injected MCT. Euthanased unrelated nasal adenocarcinoma. Side effects: ulceration. | +3 months | +104†/26 | Remission |
*Survival predicted by oncologist or veterinarian.
†Survival predicted from literature; alive=as at census date, March 1, 2016.
CFA, complete Freund’s adjuvant; FN, female neuter; MN, male neuter; ND, not determined; PI, postinjection.