Table 1

Univariate and multivariate regression analysis of mRNA PD-L1/TIM3 and PD-L1/TIGIT in the training cohort

VariablesMultivariate regression
Univariate regressionPD-L1/TIM3PD-L1/TIGIT
HR (95% CI)P valueHR (95% CI)P valueHR (95% CI)P value
PD-L1/TIM3
 Group Ireferencereference
 Group II1.79 (0.78 to 4.11)0.1661.42 (0.57 to 3.51)0.450
 Group III5.09 (1.89 to 13.67)0.0014.40 (1.55 to 12.51)0.005
PD-L1/TIGIT
 Group IVreferencereference
 Group V1.86 (0.79 to 4.36)0.1551.43 (0.57 to 3.60)0.449
 Group VI6.16 (2.18 to 17.37)0.0014.78 (1.63 to 13.96)0.004
Age, years1.04 (1.00 to 1.07)0.052
Gender
 Femalereferencereferencereference
 Male5.27 (1.22 to 22.71)0.0263.03 (0.65 to 14. 02)0.1573.49 (0.77 to 15.91)0.106
 TNM stage
 Low (I, II)referencereferencereference
 High (III, IV)2.39 (1.17 to 4.90)0.0171.75 (0.81 to 3.77)0.1551.59 (0.72 to 3.50)0.248
  • Group I, PD-L1loTIM3lo; group II, PD-L1hiTIM3lo or PD-L1loTIM3hi; group III, PD-L1hiTIM3hi; group IV, PD-L1loTIGITlo; group V, PD-L1hiTIGITlo or PD-L1loTIGIThi; and group VI, PD-L1hiTIGIThi.

  • The bold values indicate that p values <0.05 in PD-L1/TIM3 and PD-L1/TIGIT are statistically significant.

  • CI, confidence interval; HR, hazard ratio; PD-L1, programmed cell death 1 ligand 1; TIGIT, T-cell immunoglobulin and immunoreceptor tyrosine-based inhibitory motif domain; TIM3, T-cell immunoglobulin and mucin-domain-containing-3; TNM, primary tumor, regional lymph node, distant metastasis.