Univariate and multivariate regression analysis of mRNA PD-L1/TIM3 and PD-L1/TIGIT in the training cohort
| Variables | Multivariate regression | |||||
| Univariate regression | PD-L1/TIM3 | PD-L1/TIGIT | ||||
| HR (95% CI) | P value | HR (95% CI) | P value | HR (95% CI) | P value | |
| PD-L1/TIM3 | ||||||
| Group I | reference | reference | ||||
| Group II | 1.79 (0.78 to 4.11) | 0.166 | 1.42 (0.57 to 3.51) | 0.450 | ||
| Group III | 5.09 (1.89 to 13.67) | 0.001 | 4.40 (1.55 to 12.51) | 0.005 | ||
| PD-L1/TIGIT | ||||||
| Group IV | reference | reference | ||||
| Group V | 1.86 (0.79 to 4.36) | 0.155 | 1.43 (0.57 to 3.60) | 0.449 | ||
| Group VI | 6.16 (2.18 to 17.37) | 0.001 | 4.78 (1.63 to 13.96) | 0.004 | ||
| Age, years | 1.04 (1.00 to 1.07) | 0.052 | ||||
| Gender | ||||||
| Female | reference | reference | reference | |||
| Male | 5.27 (1.22 to 22.71) | 0.026 | 3.03 (0.65 to 14. 02) | 0.157 | 3.49 (0.77 to 15.91) | 0.106 |
| TNM stage | ||||||
| Low (I, II) | reference | reference | reference | |||
| High (III, IV) | 2.39 (1.17 to 4.90) | 0.017 | 1.75 (0.81 to 3.77) | 0.155 | 1.59 (0.72 to 3.50) | 0.248 |
Group I, PD-L1loTIM3lo; group II, PD-L1hiTIM3lo or PD-L1loTIM3hi; group III, PD-L1hiTIM3hi; group IV, PD-L1loTIGITlo; group V, PD-L1hiTIGITlo or PD-L1loTIGIThi; and group VI, PD-L1hiTIGIThi.
The bold values indicate that p values <0.05 in PD-L1/TIM3 and PD-L1/TIGIT are statistically significant.
CI, confidence interval; HR, hazard ratio; PD-L1, programmed cell death 1 ligand 1; TIGIT, T-cell immunoglobulin and immunoreceptor tyrosine-based inhibitory motif domain; TIM3, T-cell immunoglobulin and mucin-domain-containing-3; TNM, primary tumor, regional lymph node, distant metastasis.