Univariate and multivariate regression analysis of protein PD-L1/TIM3 and PD-L1/TIGIT in the validation cohort
| Variables | Multivariate regression | |||||
| Univariate regression | PD-L1/TIM3 | PD-L1/TIGIT | ||||
| HR (95% CI) | P value | HR (95% CI) | P value | HR (95% CI) | P value | |
| PD-L1/TIM3 | ||||||
| Group I | reference | reference | ||||
| Group II | 7.16 (0.97 to 52.75) | 0.053 | 8.56 (1.14 to 64.30) | 0.037 | ||
| Group III | 35.81 (4.27 to 300.18) | 0.001 | 47.11 (5.34 to 415.96) | 0.001 | ||
| PD-L1/TIGIT | ||||||
| Group IV | reference | reference | ||||
| Group V | 0.74 (0.38 to 1.44) | 0.380 | 0.59 (0.29 to 1.20) | 0.143 | ||
| Group VI | 5.74 (1.58 to 20.90) | 0.008 | 25.18 (3.34 to 189.74) | 0.002 | ||
| Age, years | 0.60(0.32 to 1.12) | 0.107 | ||||
| Gender | ||||||
| Female | reference | |||||
| Male | 1.59 (0.49 to 5.22) | 0.441 | ||||
| TNM stage | ||||||
| Low (I, II) | reference | reference | reference | |||
| High (III, IV) | 2.26 (1.02 to 5.03) | 0.046 | 2.36 (1.02 to 5.44) | 0.044 | 2.26 (1.00 to 5.10) | 0.049 |
Group I, PD-L1 (−)/TIM3 (−); group II, PD-L1 (+)/TIM3 (−) or PD-L1 (−)/TIM3 (+); group III, PD-L1 (+)/TIM3 (+); group IV, PD-L1 (−)/TIGIT (−); group V, PD-L1 (+)/TIGIT (−) or PD-L1 (−)/TIGIT (+); and group VI, PD-L1 (+)/TIGIT (+).
The bold values indicate that p values <0.1 in PD-L1/TIM3 and PD-L1/TIGIT are statistically significant.
PD-L1, programmed cell death 1 ligand 1; TIGIT, T-cell immunoglobulin and immunoreceptor tyrosine-based inhibitory motif domain; TIM3, T-cell immunoglobulin and mucin-domain-containing-3; TNM, primary tumor, regional lymph node, distant metastasis.