Univariate and multivariate analyses of recurrence-free and overall survival
| Parameter | Recurrence-free survival | Overall survival | |||||||
| Univariate | Multivariate | Univariate | Multivariate | ||||||
| HR (95% CI) | P value | HR (95% CI) | P value | HR (95% CI) | P | HR (95% CI) | P value | ||
| Sex | Male | 1 | 0.261 | 1 | 0.393 | ||||
| Female | 0.753 (0.459 to 1.235) | 0.809 (0.497 to 1.316) | |||||||
| Age (years) | <58 | 1 | 0.001 | 1 | 0.001 | 1 | <0.001 | 1 | <0.001 |
| ≥58 | 2.298 (1.425 to 3.704) | 2.297 (1.421 to 3.712) | 4.243 (2.448 to 7.354) | 4.243 (2.444 to 7.367) | |||||
| Histology | WD/MD | 1 | 0.665 | 1 | 0.614 | ||||
| PD/SRC | 0.904 (0.573 to 1.427) | 0.890 (0.567 to 1.398) | |||||||
| Lauren type | Intestinal | 1 | 0.994 | 1 | 0.612 | ||||
| Diffuse | 0.998 (0.638 to 1.561) | 0.891 (0.572 to 1.390) | |||||||
| T stage | pT1-2 | 1 | <0.001 | 1 | 0.002 | 1 | <0.001 | 1 | 0.003 |
| pT3-4 | 4.870 (2.679 to 8.851) | 2.637 (1.410 to 4.931) | 3.465 (2.020 to 5.942) | 2.383 (1.342 to 4.232) | |||||
| N stage | pN0 | 1 | <0.001 | 1 | <0.001 | 1 | <0.001 | 1 | 0.005 |
| pN1-3 | 7.197 (3.587 to 14.440) | 4.644 (2.236 to 9.646) | 3.590 (2.069 to 6.232) | 2.318 (1.282 to 4.190) | |||||
| Crohn-like lymphoid reaction | Score 0 | 1 | 0.991 | 1 | 0.820 | ||||
| Score 1 | 0.958 (0.505 to 1.816) | 0.823 (0.447 to 1.515) | |||||||
| Score 2–3 | 0.976 (0.508 to 1.873) | 0.863 (0.464 to 1.604) | |||||||
| Peritumoral lymphoid reaction | Score 0 | 1 | 0.439 | 1 | 0.356 | ||||
| Score 1 | 0.692 (0.393 to 1.218) | 0.698 (0.390 to 1.250) | |||||||
| Score 2–3 | 0.758 (0.409 to 1.404) | 0.947 (0.516 to 1.737) | |||||||
| Intratumoral lymphoid reaction | Score 0 | 1 | 0.034 | 1 | 0.075 | 1 | 0.024 | 1 | 0.078 |
| Score 1 | 0.477 (0.235 to 0.968) | 0.554 (0.270 to 1.134) | 0.468 (0.238 to 0.921) | 0.586 (0.294 to 1.168) | |||||
| Score 2–3 | 0.336 (0.147 to 0.768) | 0.375 (0.161 to 0.874) | 0.332 (0.149 to 0.740) | 0.388 (0.170 to 0.883) | |||||
| Overall lymphoid reaction | Score 0–2 | 1 | 0.588 | 1 | 0.675 | ||||
| Score 3–6 | 0.784 (0.467 to 1.315) | 0.792 (0.472 to 1.330) | |||||||
| Score 7–9 | 0.691 (0.278 to 1.722) | 0.814 (0.344 to 1.927) | |||||||
| HEV density | Low | 1 | <0.001 | 1 | 0.001 | 1 | <0.001 | 1 | 0.020 |
| High | 0.281 (0.167 to 0.473) | 0.412 (0.241 to 0.705) | 0.382 (0.235 to 0.623) | 0.547 (0.329 to 0.909) | |||||
.HEV, high endothelial venule; MD, moderate differentiated; OS, overall survival; PD, poorly differentiated; SRC, signet ring cell; WD, well differentiated.