Table 1

Patient demographics (n=26)

AgeMedian (range)57.6 (30.1–82.8)
GenderMale17
Female9
American Joint Committee on Cancer stageIII4
M1A0
M1B3
M1C11
M1D7
Primary siteCutaneous17
Acral4
Subungual1
Unknown primary4
Driver mutationBRAF10
NRAS5
Other*2
No driver identified6
Not tested3
Tumor mutation burdenHigh11
Low11
Unknown4
First course of ipi/nivoMedian # doses (range)4 (1–4)
# of patients receiving maintenance anti-PD116
Reinduction course of ipi/nivoMedian # of doses (range)3 (1–4)
Months between coursesMedian (range)22.2 (6–49.1)
  • *One patient had KRAS G12V; the other had two NF1 alterations, X421_splice and Q392* and SF3B1 G740E.

  • ipi/nivo, ipilimumab/nivolumab.