NIZ985 pharmacokinetic parameters
| Participant | Dose (µg/kg) | Cmax (pg/mL) | Tmax (hr) | AUClast (pg·h/mL) | Clast (pg/mL) | Tlast (h) |
| 1 | 1 | 132 | 24.0 | 4085 | 52.6 | 44.4 |
| 2 | 1 | 120 | 27.4 | 2838 | 120 | 27.4 |
| 3 | 2 | 185 | 23.0 | 5126 | 56.1 | 46.1 |
| 4 | 2 | 138 | 12.0 | 3975 | 60.3 | 43.0 |
| 5 | 4 | 461 | 7.17 | 10 910 | 70.3 | 49.1 |
NIZ985 concentrations in the 0.25 ug/kg and 0.5 ug/kg TIW cohorts were below the assay LLOQ (50 pg/mL). In these two cohorts, samples were analyzed beyond the current demonstrated stability period of 710 days. Hence, measurements from these cohorts were not reported.
AUClast, area under the NIZ985 concentration–time curve from 0 to Tlast; Clast, last quantifiable NIZ985 serum concentration; Cmax, maximum NIZ985 serum concentration; Tlast, time post-dose of Clast; Tmax, time post-dose of Cmax.