Tumor immune microenvironment cell types estimated by TIMEx signatures found to be significantly enriched in unknown primary melanomas compared with known primary and vice versa as computed by GSEA (NES: Normalized Enrichment Score)
| NES | NOM p value | FDR q value | |
| Enriched in unknown primary tumors | |||
| IMMUNE_CD8TEX | 2.53 | 0.0000 | 0.0000 |
| IMMUNE_B | 2.34 | 0.0000 | 0.0000 |
| IMMUNE_NK | 2.22 | 0.0000 | 0.0000 |
| IMMUNE_PLASMA | 2.21 | 0.0000 | 0.0000 |
| IMMUNE_CD4TCONV | 2.17 | 0.0000 | 0.0000 |
| IMMUNE_CD8T | 2.15 | 0.0000 | 0.0000 |
| MINOR_CD8TCM | 2.13 | 0.0000 | 0.0000 |
| MINOR_CD4TN | 2.11 | 0.0000 | 0.0000 |
| IMMUNE_TMKI67 | 1.98 | 0.0000 | 0.0000 |
| MINOR_TH1 | 1.95 | 0.0000 | 0.0000 |
| IMMUNE_DC | 1.94 | 0.0000 | 0.0000 |
| MINOR_CDC2 | 1.91 | 0.0000 | 0.0001 |
| MINOR_CD8TEFF | 1.90 | 0.0000 | 0.0001 |
| MINOR_CD4TEFF | 1.89 | 0.0000 | 0.0001 |
| MINOR_M1 | 1.87 | 0.0000 | 0.0001 |
| IMMUNE_PDC | 1.82 | 0.0000 | 0.0004 |
| IMMUNE_TREG | 1.82 | 0.0000 | 0.0003 |
| MINOR_MONOCYTE | 1.51 | 0.0079 | 0.0168 |
| MINOR_TH17 | 1.50 | 0.0361 | 0.0184 |
| IMMUNE_NEUTROPHILS | 1.50 | 0.0162 | 0.0184 |
| IMMUNE_ILC | 1.38 | 0.0666 | 0.0467 |
| Enriched in known primaries | |||
| STROMAL_FIBROBLASTS | −1.51 | 0.0000 | 0.0799 |
| STROMAL_MYOFIBROBLASTS | −1.48 | 0.0000 | 0.0484 |
FDR, false discovery rate; GSEA, gene set enrichment analysis.