Table 1

Immune related pathways found to be significantly enriched in unknown primary melanomas compared with known primary as computed by gene set enrichment analysis (using KEGG pathways gene sets) (NES: Normalized Enrichment Score)

KEGG pathways	NES	NOM p value	FDR q value
Antigen processing and presentation	2.28	0.0000	0.0000
Autoimmune thyroid disease	2.25	0.0000	0.0000
Allograft rejection	2.22	0.0000	0.0000
Systemic lupus erythematosus	2.21	0.0000	0.0000
Intestinal immune network for iga production	2.11	0.0000	0.0002
Graft versus host disease	2.07	0.0000	0.0001
Leishmania infection	1.98	0.0000	0.0007
Primary immunodeficiency	1.96	0.0000	0.0011
Type I diabetes mellitus	1.94	0.0000	0.0011
DNA Replication	1.70	0.0097	0.0386
Toll like receptor signaling pathway	1.69	0.0000	0.0364
Viral myocarditis	1.69	0.0031	0.0342
Pantothenate and Coa Biosynthesis	1.68	0.0203	0.0358
Prion diseases	1.63	0.0084	0.0564
Natural killer cell mediated cytotoxicity	1.63	0.0030	0.0531
Protein export	1.62	0.0188	0.0529
Asthma	1.59	0.0223	0.0633
Starch and sucrose metabolism	1.57	0.0161	0.0776
Complement and coagulation cascades	1.56	0.0142	0.0774
Cell adhesion molecules cams	1.55	0.0031	0.0777

FDR, false discovery rate; NOM p-val, Nominal p value.