Table 1

Dose groups—lymphodepletion and cell doses

Dose groupLymphodepleting chemotherapyTransduced ADP-A2M10 (range)Patient ID
1Cyclophosphamide 1800 mg/m2/day on days −7 and –60.1×109
(0.08×109–0.12×109)
1–5
2Cyclophosphamide 600 mg/m2/day and fludarabine 30 mg/m2/day on days –7, –6, and –51.0×109
(0.5×109–1.2×109)
6–8
3Cyclophosphamide 600 mg/m2/day on days –7, –6, and –5, and fludarabine 30 mg/m2/day on days –7, –6, –5, and –45.0×109
(1.2×109–6×109)
9–10
Expansion groupCyclophosphamide 1800 mg/ m2/day on days –3 and –2, and fludarabine 30 mg/m2/day on days –5, –4, –3, and –25.0×109
(1.2×109–15×109)
9*
Cyclophosphamide 600 mg/m2/day on days –7, –6, and –5, and fludarabine 30 mg/m2/day on days –7, –6, –5, and –45.0×109
(1.2×109–15×109)
11
  • *One patient (patient 9) received a second infusion at this schedule of cyclophosphamide and fludarabine and ADP-A2M10.

  • ID, identifier.