Description of patients across cancer types
| Toxicity grade <2 (n=116) | Toxicity grade ≥2 (n=45) | Overall (N=161) | P value | |
| Total cycles, median (IQR) | 9 (12) | 15 (18) | 10 (15) | 0.229 |
| Toxicity cycle, median (IQR) | – | 8 (16) | – | |
| Male, % (n) | 69 (80) | 78 (35) | 71 (115) | 0.322 |
| Age, mean (SD) | 66 (14) | 67 (11) | 67 (13) | 0.691 |
| Cancer type, % (n) | 0.425 | |||
| Melanoma | 35 (41) | 47 (21) | 39 (62) | |
| Prostate | 23 (27) | 20 (9) | 22 (36) | |
| Other | 41 (48) | 33 (15) | 39 (63) | |
| HNSCC | 5 (6) | 0 (0) | 4 (6) | |
| GU | 9 (11) | 18 (8) | 12 (19) | |
| GYN | 3 (4) | 2 (1) | 3 (5) | |
| NSCLC | 9 (11) | 13 (6) | 11 (17) | |
| Miscellaneous (sarcoma, GYN, breast, GBM, GI) | 14 (16) | 0 (0) | 10 (16) | |
| Toxicity type, % (n) | ||||
| Adrenal | – | 13 (6) | – | |
| Arthritis | – | 4 (2) | – | |
| Skin | – | 36 (16) | – | |
| Colitis | – | 18 (8) | – | |
| Fatigue | – | 2 (1) | – | |
| Muscular/skeletal | – | 7 (3) | – | |
| Kidney | – | 2 (1) | – | |
| Liver | – | 13 (6) | – | |
| Lung | – | 9 (4) | – | |
| Neurologic | – | 4 (2) | – | |
| Thyroid | – | 16 (7) | – | |
| Cardiac | – | 2 (1) | – |
The reported p values are associated with independent z tests for difference in mean for continuous variables, z tests for differences in proportions for counting variables, and χ2 tests for categorical variables.
GBM, glioblastoma multiforme; GI, gastrointestinal; GU, genitourinary cancer; GYN, gynecological; HNSCC, head and neck cancer; NSCLC, non-small cell lung cancer.