Marker | Tissue | Predose control, cells* | Duration, day | AUC, cells* day† | ||
Mean±SD | IL-15 5 µg once a day×5 | MS~IL-1550 μg | IL-15 5 µg once a day×5 | MS~IL-1550 μg | ||
NK1.1+ | Spleen | 0.93±0.16 | 14 | 14 | 10 | 19 |
ln | 0.24±0.03 | 14 | 14 | 0.71 | 1.5 | |
PBMC | 0.21±0.04 | 14 | 14 | 5.4 | 12 | |
CD8+ | Spleen | 6.34±1.32 | 14 | 14 | 51 | 82 |
ln | 13.6±3.67 | 14 | 14 | 94 | 130 | |
PBMC | 0.65±0.16 | 21 | 21 | 8.0 | 7.1 | |
CD44hiCD8+ | Spleen | 1.32±0.20 | 28 | 28 | 46 | 69 |
ln | 1.95±1.85 | 28 | 28 | 70 | 104 | |
PBMC | 0.13±0.03 | 28 | 28 | 6.5 | 7.0 | |
TCRɣδ+ | Spleen | 0.55±0.09 | 14 | 14 | 3.9 | 10 |
ln | 0.66±0.08 | 14 | 14 | 4.2 | 8.1 | |
PBMC | 0.04±0.01 | 21 | 14 | 0.48 | 0.48 | |
Ki67+ NK1.1+ | Spleen | 0.14±0.05 | 7 | 7 | 6.8 | 6.0 |
ln | 0.05±0.01 | 7 | 7 | 1.1 | 1.5 | |
PBMC | 0.03±0.01 | 14 | 14 | 2.3 | 2.5 | |
Ki67+CD44hiCD8+ | Spleen | 0.47±0.16 | 7 | 7 | 15 | 18 |
ln | 0.65±0.21 | 7 | 7 | 16 | 26 | |
PBMC | 0.03±0.01 | 21 | 14 | 1.6 | 1.1 | |
Ki67+ TCRɣδ+ | Spleen | 0.26±0.05 | 14 | 14 | 3.5 | 8.6 |
ln | 0.36±0.07 | 14 | 14 | 2.3 | 6.1 | |
PBMC | 0.020±0.005 | 21 | 21 | 0.54 | 0.6 |
*Control values are cells×10−6 for spleen and lymph nodes (ln), and cells/μL×10−3 for PBMCs.
†AUC values are cells×10−6×day for spleen and ln, and cells/μL×10−3×day for PBMCs.
AUC, area under the curve; IL, interleukin; MS, microspheres; PBMC, peripheral blood mononuclear cell.