Association between IL1R1/CD274 (PD-L1) expression and molecular parameters
| Factors | IL1R1hi CD274hi | IL1R1lo CD274hi | IL1R1hi CD274lo | IL1R1lo CD274lo | P value |
| All patients | 12 | 11 | 11 | 11 | |
| Immune signature | 0.001 | ||||
| High | 9 | 9 | 3 | 1 | |
| Low | 3 | 2 | 8 | 10 | |
| Mutation load | 0.016 | ||||
| High | 0 | 5 | 1 | 1 | |
| Moderate | 2 | 4 | 5 | 6 | |
| Low | 10 | 2 | 5 | 4 | |
| EMT status | 1.000 | ||||
| Mesenchymal | 2 | 1 | 2 | 1 | |
| Non-mesenchymal | 10 | 10 | 9 | 10 | |
| Molecular subtype | 0.002 | ||||
| CIN | 5 | 2 | 3 | 6 | |
| EBV | 0 | 4 | 0 | 0 | |
| GS | 7 | 1 | 7 | 5 | |
| MSI | 0 | 4 | 1 | 0 | |
| MSI status | 0.020 | ||||
| High | 0 | 4 | 1 | 0 | |
| Low | 12 | 7 | 10 | 11 | |
| EBV status | 0.007 | ||||
| Positive | 0 | 4 | 0 | 0 | |
| Negative | 12 | 7 | 11 | 11 | |
| Response | 0.003 | ||||
| PD | 7 | 2 | 5 | 4 | |
| SD | 4 | 0 | 5 | 6 | |
| PR | 1 | 6 | 1 | 1 | |
| CR | 0 | 3 | 0 | 0 |
P<0.05 marked in bold font shows statistical significance.
CIN, chromosomal instability; CR, complete response; EBV, EBV positive; EMT, epithelial-mesenchymal transition; GS, genomically stable; hi, high; lo, low; MSI, microsatellite instability; PD, progressive disease; PR, partial response; SD, stable disease.