Table 2

Features contributing to ArcTIL model. A HR >1 implies that feature has a positive correlation with risk of having event (death), while a HR <1 implies the opposite

Feature indexCompartmentFeature descriptionHR (per unit increase)
1EpithelialRatio of non-TILs density to the surrounding* TIL one in the epithelium.1.84
2Number of epithelial TIL clusters surrounding* a non-TIL cluster.0.84
3StromalPresence percentage† of stromal non-TIL clusters being around another non-TIL cluster.1.34
4Range of density of TIL clusters to the surrounding* non-TIL ones in stroma.0.76
5Tumor edgeIntersected area of clusters of epithelial TILs and non-TILs.0.69
6Minimum area of S-TILs clusters.1.49
7Range of area of epithelial non-TIL clusters.1.31
  • *Surrounding means being at the 20 microns proximity.

  • †Presence percentage means the ratio of the present clusters to the total number of clusters.

  • S-TIL, stromal TIL; TIL, tumor-infiltrating lymphocyte.