Feature index | Compartment | Feature description | HR (per unit increase) |
1 | Epithelial | Ratio of non-TILs density to the surrounding* TIL one in the epithelium. | 1.84 |
2 | Number of epithelial TIL clusters surrounding* a non-TIL cluster. | 0.84 | |
3 | Stromal | Presence percentage† of stromal non-TIL clusters being around another non-TIL cluster. | 1.34 |
4 | Range of density of TIL clusters to the surrounding* non-TIL ones in stroma. | 0.76 | |
5 | Tumor edge | Intersected area of clusters of epithelial TILs and non-TILs. | 0.69 |
6 | Minimum area of S-TILs clusters. | 1.49 | |
7 | Range of area of epithelial non-TIL clusters. | 1.31 |
*Surrounding means being at the 20 microns proximity.
†Presence percentage means the ratio of the present clusters to the total number of clusters.
S-TIL, stromal TIL; TIL, tumor-infiltrating lymphocyte.