Table 2

The relationship between PD-1 expression and clinical-pathologic features of human colon cancer

	N	%	PD-1 tumor expression				P value
	N	%	Negative (n=37)	%	Positive (n=11)	%	P value
Age (years)							0.390
27–64	18	37.50	13	35.1	5	45.5
≥65	30	62.50	24	64.9	6	54.5
Gender							0.731
Female	24	50.00	18	48.6	6	54.5
Male	24	50.00	19	51.4	5	45.5
Tumor localization							0.731
Left-sided colon	24	50.00	18	48.6	6	54.5
Right-sided colon	24	50.00	19	51.4	5	45.5
DNA mismatch repair (MMR) deficiency							0.132
No	18	37.50	16	43.2	2	18.2
Yes	30	62.50	21	56.8	9	81.8
Grading							0.786
Differentiated	1	2.08	1	2.7	0	0
Moderately differentiated	45	93.75	34	91.9	10	90.9
Poorly differentiated	3	6.25	2	5.41	1	9.09
AJCC stage							0.241
I	18	37.50	14	37.8	4	36.4
IIA	11	22.92	10	27	1	9.09
IIB	1	2.08	0	0	1	9.09
IIIA	4	8.33	3	8.11	1	9.09
IIIB	8	16.67	6	16.2	2	18.2
IIIC	1	2.08	0	0	1	9.09
IV	5	10.42	4	10.8	1	9.09
pT							0.041
1	6	12.50	4	10.8	1	9.09
2	18	37.50	13	35.1	5	45.5
3	23	47.92	20	54.1	3	27.3
4	2	4.17	0	0	2	18.2
pM							0.87
0	43	89.58	33	89.2	10	90.9
1	5	10.42	4	10.8	1	9.09
N							0.47
0	34	70.83	27	73	6	54.5
1	8	16.67	5	13.5	3	27.3
2	7	14.58	5	13.5	2	18.2
Tumor budding							0.335
None	22	45.83	15	40.5	7	63.6
Low grade	9	18.75	7	18.9	2	18,2
High grade	17	35.42	15	40.5	2	18.2
Vascular invasion							0.587
No	36	83.72	29	85.3	7	77.8
Yes	7	16.28	5	14.7	2	22.2
Lymphocytic/monocytic infiltration							0.253
None	8	18.60	5	14.7	3	33.3
Moderate	13	30.23	12	35.3	1	11.1
High	22	51.16	17	50	5	55.6
Distant progression							0.646
No	29	63.04	23	65.7	6	54.5
Yes	17	36.96	12	34.3	5	45.5
Survival status							0.955
Live	29	67.44	23	67.6	6	66,7
Dead	14	32.56	11	32.4	3	33.3