Table 2

Distribution of each biomarker, such as RRS, age, sex, race, tumor histology, tumor stage, PD-L1 expression, and smoking status, based on low-risk and high-risk groups

BiomarkerHigh-riskLow-riskP value
RRSMedian=0.47
95% CI 0.53 to 0.92		Median=0.6
95% CI −0.87 to −0.59		1.14e-21
PD-L18 high PD-L1
38 low PD-L1
14 N/A		25 high PD-L1
23 low PD-L1
11 N/A		0.0012
Smoking16 current smoker
45 never or former		18 current smoker
41 never or former		0.68
Pack per yearMedian=45.5
95% CI 42.6 to 56.9		Median=42
95% CI 38.55 to 51.27		0.32
AgeMedian=66
95% CI 64.8 to 68.6		Median=69
95% CI 67.23 to 71.95		0.63
Sex23 male
28 female		28 male
31 female		0.58
Race49 white
11 black		46 white
13 black		0.65
Tumor histology28 squamous
27 adenocarcinoma
5 large cell carcinoma		27 squamous
32 adenocarcinoma
1 large cell carcinoma		0.24
Stage25 stage IIIA
32 stage IIIB
3 stage IIIC		29 stage IIIA
27 stage IIIB
3 stage IIIC		0.72

  • N/A, not available; PD-L1, programmed cell death ligand-1; RRS, radiomic signature risk score.