Table 2

Adverse events

Arm 3Arm 4
Grade 1Grade 2Grade 3Grade 4Grade 1Grade 2Grade 3Grade 4
 Adrenal insufficiency1
 Hyperthyroidism/decreased TSH23132
 Hypothyroidism/increased TSH54
 Abdominal pain11
 Injection site reaction55
Laboratory investigations
 Increased AST11
 Increased amylase11
Metabolism and nutrition
Musculoskeletal and connective tissue
 Back pain11
 Bone pain111
 Muscle weakness11
Nervous system
Respiratory, thoracic
Skin and subcutaneous
 Rash maculopapular1121
  • All adverse events with a frequency >5%, and any adverse events with grade >grade 2, that were believed to be at least possibly related to treatment are shown for patients treated in arms 3 and 4. The numbers represent the number of patients experiencing a particular event at any point during the treatment period, with the highest grade reported for any single individual.

  • TSH, thyroid-stimulating hormone.