Table 2

Variables associated with survival on univariable and multivariable analyses in 1620 patients with colon and 1243 patients with rectal cancer, by tumor location

Univariable analyses
Colon				Rectum
Factor	P value			Factor	P value
Factor	DFS	OS	DSS	Factor	OS	DSS
Age	<0.001	<0.001	0.03	Male	0.001
T stage		<0.001	0.001	Age	<0.001	<0.001
N stage		<0.001		T stage	<0.001	<0.001
M stage		<0.001	<0.001	N stage	<0.001	<0.001
TNM stage	<0.001	<0.001	<0.001	M stage	<0.001	<0.001
Histologic grade	<0.001	<0.001		TNM stage	<0.001	<0.001
VI		<0.001	<0.001	Histologic grade	<0.001	<0.001
LVI		<0.001		VI	<0.001	<0.001
HLA-B/C	0.01	<0.001		LVI	0.02
				KRAS	0.02
				CEA	<0.001	<0.001
				HLA-B/C	<0.001	<0.001

Multivariable analyses
Colon				Rectum
Factor	P value			Factor	P value
Factor	DFS	OS	DSS	Factor	OS	DSS
Study	0.001	0.001	0.03	Study	<0.001	<0.001
Age	<0.001	<0.001		Age	<0.001	<0.001
TNM stage	<0.001	<0.001	<0.001	TNM stage	<0.001	<0.001
Histologic grade	<0.001	<0.001		Histologic grade	<0.001	<0.001
HLA-B/C	0.006	<0.001		HLA-B/C	<0.001

DFS is not shown for rectal tumors since only one study provided such data. P values derived from log-rank test and Cox regression models for univariable and multivariable analyses, respectively.
CEA, carcinoembryonic antigen; DFS, disease-free survival; DSS, disease-specific survival; HLA, human leucocyte antigen; LVI, lymphovascular invasion; OS, overall survival; TNM, tumor, node, metastasis; VI, vascular invasion.