Table 4

Plasma proteins differentially expressed with itacitinib plus epacadostat or parsaclisib treatment

Plasma proteinLog2 fold change in protein level*
Treatment group A: itacitinib 300 mg plus epacadostat 300 mg (n=12)
NCR1Natural cytotoxicity triggering receptor 1 (CD335)−0.52569
IL2-RAInterleukin 2 receptor alpha chain (CD25)−0.46984
TNFSF13BTNFSF member 13B (BAFF or CD257)−0.45461
CYR61Cysteine-rich angiogenic inducer 610.464913
FGF-19Fibroblast growth factor 191.133495
Treatment groups B-1 and B-2: itacitinib 300 mg plus parsaclisib 10 mg (n=12)
CD160Natural killer cell receptor, Ig superfamily member−1.12002
CXCL13CXC motif chemokine ligand 13−0.93206
FCER2Fc epsilon RII (CD23)−0.84571
TNFRSF9TNFRSF member 9 (CD137)−0.79495
XCL1C motif chemokine ligand 1 (lymphotactin)−0.78599
NCR1Natural cytotoxicity triggering receptor 1 (CD335)−0.76039
FASLGFas ligand (TNFSF6 or CD95L)−0.74582
SIGLEC6Sialic acid binding Ig-like lectin 6−0.64892
IL12Interleukin 12−0.6411
TRANCE†TNF-related activation-induced cytokine−0.63516
CD5Lymphocyte antigen T1−0.62866
FcRL2Fc receptor-like protein 2−0.6028
TNFBTNF-beta (TNFSF1 or lymphotoxin-alpha)−0.60078
IL-12BInterleukin 12 subunit beta−0.5857
FcRL6Fc receptor-like protein 6−0.5821
SIT1Signaling threshold-regulating transmembrane adapter 1−0.52955
LAIR-2Leukocyte-associated immunoglobulin-like receptor 2 (CD306)−0.50665
TNFRSF4TNFRSF member 4 (OX40 receptor or CD134)−0.4735
LILRB4Leukocyte Ig-like receptor subfamily B member 4−0.43298
TNFRSF13BTNFRSF member 13B (CD267)−0.42143
MUC-16Mucin 160.408191
ST3GAL1ST3 beta-galactoside alpha-2,3-sialyltransferase 10.425019
REG4Regenerating islet-derived protein 40.428488
SMOC2SPARC-related modular calcium-binding protein 20.437624
Flt3LFMS-like tyrosine kinase 3 ligand0.514995
  • *Baseline (C1D1) vs on-treatment (C2D1) samples were compared using a paired t-test, with changes considered significant at FDR p<0.05 and a log2 fold change >0.4 or <−0.4.

  • †Receptor activator of nuclear factor kappa-Β ligand (RANKL) or TNFSF11.

  • BAFF, B cell activating factor; C1D1, cycle 1 day 1; C2D1, cycle 2 day 1; CD, cluster of differentiation; FDR, false discovery rate; Ig, immunoglobulin; TNF, tumor necrosis factor; TNFRSF, tumor necrosis factor receptor superfamily; TNFSF, tumor necrosis factor ligand superfamily.