Characteristics associated with the TLSs in 105 human ccRCC tumor samples
| Characteristics | All patients n=105 | TLS negative n=72 | TLS positive n=33 | P value |
| Sex, no (%) | 0.320 | |||
| Male | 76 (72) | 50 (70) | 26 (79) | |
| Female | 29 (28) | 22 (30) | 7 (21) | |
| Age at surgery, no (%) | 0.160 | |||
| <60 year | 52 (50) | 39 (54) | 13 (39) | |
| >60 years | 53 (50) | 33 (46) | 20 (61) | |
| Pathological T stage, no (%) | 0.362 | |||
| pT1/2 | 64 (61) | 46 (64) | 18 (55) | |
| pT3/4 | 41 (39) | 26 (36) | 15 (45) | |
| Tumor grade, no (%) | 0.038 | |||
| G1/2 | 69 (66) | 52 (72) | 17 (51) | |
| G3/4 | 36 (34) | 20 (28) | 16 (49) | |
| Venous invasion, no (%) | 0.465 | |||
| Negative | 75 (71) | 53 (74) | 22 (67) | |
| Positive | 30 (29) | 19 (26) | 11 (33) | |
| Tumor size, no (%) | 0.264 | |||
| <60 mm | 53 (50) | 39 (54) | 14 (42) | |
| >60 mm | 52 (50) | 33 (46) | 19 (58) | |
ccRCC, clear cell renal cell carcinoma; TLS, tertiary lymphoid structure.