Table 3

Parameters associated with postoperative disease recurrence and overall mortality of ccRCC patients after adjusting for confounding variables in the univariate and multivariate Cox regression analyses

VariablesDisease-free survivalOverall survival
P valueHR (95% CI)P valueP valueHR (95% CI)P value
Sex (male vs female)0.7130.072
Age at surgery (>60 years vs <60 years)0.2220.0072.57 (1.14 to 5.74)0.022
Pathological T stage (pT3/4 vs pT1/2)<0.0011.94 (1.08 to 3.46)0.026<0.001
Tumor grade (G3/4 vs G1/2)<0.0013.00 (1.68 to 5.36)<0.001<0.0014.74 (2.18 to 10.27)<0.001
Venous invasion (positive vs negative)0.0560.190
Tumor size (>60 mm vs <60 mm)<0.0010.009
TLS (positive vs negative)<0.0012.57 (1.50 to 4.40)0.001<0.0013.04 (1.42 to 6.48)0.004
  • ccRCC, clear cell renal cell carcinoma; TLS, tertiary lymphoid structure.