Table 1

Univariate and multivariate survival analysis in GC NAC cohort

Characteristics		Number		Univariate		Multivariate
Characteristics	Class	Total	Event (OS)	HR (95% CI)	P value	HR (95% CI)	P value
Age				1.006 (0.991 to 1.020)	0.450
Histology	Adenocarcinoma	283	161	1		1
	Signet-ring cell carcinoma (SRCC)	19	15	1.772 (1.043 to 3.009)	0.034	1.993 (0.968 to 4.105)	0.061
Differentiation
	Poor	135	91	1		1
	Well/moderate	144	74	0.632 (0.465 to 0.859)	0.003	0.636 (0.439 to 0.922)	0.017
Tumor diameter
	<5 cm	151	72	1
	≥5 cm	137	97	1.870 (1.378 to 2.538)	<0.001
Vascular invasion
	Negative	174	80	1
	Positive	123	93	2.605 (1.926 to 3.523)	<0.001
NAC response
	Responders	28	10	1
	Non-responders	276	167	2.116 (1.118 to 4.007)	0.021
pTNM
	I	23	1	1		1
	II	95	30	7.711 (1.051 to 56.543)	0.045	3.627 (0.488 to 26.968)	0.208
	III	127	99	30.607 (4.263 to 219.727)	0.001	12.691 (1.760 to 91.496)	0.012
	IV	43	39	47.637 (6.530 to 347.492)	<0.001	17.340 (2.346 to 128.150)	0.005
CD3				0.982 (0.965 to 0.999)	0.043
CD8				0.972 (0.953 to 0.991)	0.004	0.967 (0.946 to 0.989)	0.004
CD4				0.984 (0.957 to 1.012)	0.255
FOXP3				1.004 (0.906 to 1.113)	0.944
Granzyme B				0.943 (0.860 to 1.035)	0.220
CD20				1.004 (0.982 to 1.027)	0.725
CD68				0.997 (0.963 to 1.032)	0.873
CD57				1.009 (0.987 to 1.032)	0.439