Summary of adverse events of any grade and of grade ≥3 adverse events
| Adverse event | No of patients having an adverse event (%) N=221 | |||
| All grades | Grade ≥3 | |||
| Irrespective of relationship | Related | Irrespective of relationship | Related | |
| Total no of patients with an event | 218 (98.6) | 196 (88.7) | 157 (71.0) | 111 (50.2) |
| Total no of events | 2759 | 1303 | 424 | 171 |
| Decreased appetite | 87 (39.4) | 44 (19.9) | 8 (3.6) | 5 (2.3) |
| Fever | 80 (36.2) | 48 (21.7) | 3 (1.4) | 2 (0.9) |
| Fatigue | 78 (35.3) | 53 (24.0) | 18 (8.1) | 14 (6.3) |
| Anemia | 68 (30.8) | 15 (6.8) | 33 (14.9) | 8 (3.6) |
| Asthenia | 66 (29.9) | 46 (20.8) | 18 (8.1) | 13 (5.9) |
| Periorbital edema | 65 (29.4) | 63 (28.5) | 3 (1.4) | 3 (1.4) |
| Face edema | 61 (27.6) | 58 (26.2) | 2 (0.9) | 2 (0.9) |
| Diarrhea | 59 (26.7) | 33 (14.9) | 3 (1.4) | 3 (1.4) |
| Rash | 59 (26.7) | 57 (25.8) | 14 (6.3) | 14 (6.3) |
| Nausea | 56 (25.3) | 25 (11.3) | 4 (1.8) | 0 |
| Pruritus | 56 (25.3) | 53 (24.0) | 5 (2.3) | 5 (2.3) |
| Dyspnea | 51 (23.1) | 11 (5.0) | 7 (3.2) | 0 |
| Eyelid edema | 43 (19.5) | 43 (19.5) | 3 (1.4) | |
| Cough | 42 (19.0) | 12 (5.4) | 1 (0.5) | 1 (0.5) |
| Aspartate aminotransferase increased | 39 (17.6) | 28 (12.7) | 12 (5.4) | 8 (3.6) |
| Constipation | 39 (17.6) | 6 (2.7) | 0 | 0 |
| Edema peripheral | 34 (15.4) | 26 (11.8) | 3 (1.4) | 0 |
| Vomiting | 31 (14.0) | 10 (4.5) | 1 (0.5) | 0 |
| Abdominal pain | 27 (12.2) | 3 (1.4) | 3 (1.4) | 1 (0.5) |
| Headache | 25 (11.3) | 12 (5.4) | 2 (0.9) | 1 (0.5) |
| Lacrimation increased | 23 (10.4) | 21 (9.5) | 0 | 0 |
| Dry skin | 23 (10.4) | 17 (7.7) | 0 | 0 |
| Chills | 22 (10.0) | 13 (5.9) | 0 | 0 |
| Hypophosphatemia | 22 (10.0) | 3 (1.4) | 18 (8.1) | 2 (0.9) |
For overall adverse events, only adverse events of any grade reported by >10% of patients are shown.