Table 1

List of 29 cytokines differentially expressed between cell free pleural fluid and plasma of LUAD patients

MPEs concentration (pg/mL)Plasma concentration (pg/mL)Fold MPEs/plasmaP value
SCGF-b83 287.1 (±8944)25 082.5 (±3814)3.3<0.0001
IL-6940.1 (±158.3)2.3 (±0.9)413.9<0.0001
HGF458.1 (±87.1)177.5 (±41.8)2.60.0205
IP-10 (CXCL10)370.5 (±82.6)54.3 (±6.1)6.80.0018
MCP-1 (CCL2)162.3 (±31.4)16.6 (±2.7)9.80.0005
IL-870.5 (±15.3)8.2 (±3.1)8.60.0008
SCF70.0 (±8.4)20.1 (±1.7)3.5<0.0001
IL-2Ra69.2 (±8.9)27.9 (±2.3)2.50.0001
IL-559.1 (±6.4)7.0 (±3.1)8.4<0.0001
G-CSF44.3 (±7.6)21.0 (±3.3)2.10.0021
IL-12 (p40)43.0 (±5.1)25.0 (±3.0)1.70.0200
GRO-a (CXCL1)34.7 (±30.7)198.1 (±58.4)0.20.0355
LIF30.7 (±4.5)10.3 (±0.9)3.00.0008
IL-926.3 (±4.5)62.7 (±8.5)0.40.0022
TNF-b24.4 (±4.1)57.2 (±7.7)0.40.0023
TRAIL23.2 (±2.3)17.4 (±1.3)1.30.0363
IFN-g22.9 (±2.6)7.5 (±1.3)3.0<0.0001
IL-1817.1 (±2.5)28.7 (±3.6)0.60.0282
MIP-1b (CCL4)16.8 (±1.8)37.6 (±4.4)0.40.0008
IL-1a6.1 (±0.5)3.8 (±0.7)1.60.0278
M-CSF5.8 (±0.6)7.6 (±1.1)0.80.0274
IL-105.2 (±0.6)1.3 (±0.3)4.10.0002
MCP-3 (CCL7)3.8 (±1.1)0.7 (±0.1)5.20.0132
IFN-a23.4 (±0.2)2.5 (±0.3)1.40.0284
IL-72.5 (±0.2)1.6 (±0.3)1.60.0008
MIP-1a (CCL3)1.7 (±0.2)0.7 (±0.1)2.50.0001
IL-1b0.9 (±0.1)0.5 (±0.1)1.70.0015
IL-130.5 (±0.04)0.4 (±0.05)1.50.0026
IL-40.5 (±0.03)0.3 (±0.03)1.60.0006
  • Cytokines are listed based on the higher concentration in MPEs. Mean values of concentration ±SEM (n=15) are reported for each cytokine in each group. Fold is considered statistically significant if p<0.05 (two-tailed Student’s t-test).

  • LUAD, lung adenocarcinoma; MPEs, malignant pleural effusions.