Table 2

Treatment related AEs

TRAETotal (N=34)All AEsGuadecitabine dose levelAll AEsAll AEs
EscalationAll AEsEscalationExpansion
45 mg/m2 (N=6)30 mg/m2 (N=8)30 mg/m2 (N=20)
Grade≥Grade 3≥Grade 3≥Grade 3≥Grade 3
Any TRAE18 (53%)536 (100%)165 (62.5%)108 (40%)27
Neutropaenia1320463569
Fatigue06010104
Febrile Neutropaenia44221111
Anemia03000003
Nausea04010003
Thrombocytopaenia03020001
Anemia02000111
Cough02000002
Diarrhea12001200
Fever02010001
Injection site reaction02010001
Rash02010001
Vomiting02010001
  • AEs, adverse events; TRAE, treatment related AEs.